Larazotide acetate

Research use only, not for human use.

Larazotide acetate is a synthetic peptide. It functions as a tight junction regulator and reverses leaky junctions to their normally closed state.

Larazotide acetate is a synthetic peptide. It functions as a tight junction regulator and reverses leaky junctions to their normally closed state. (In Vitro):Larazotide acetate (1-100 μM; 5 d) affects Vero cell growth.Larazotide acetate (1-100 μM; 3 d) shows antiviral activity to varicella-zoster virus (VZV) with EC50s of 44.14 and 59.06 μM for strain OKA and 07-1, respectively.Larazotide acetate (1 and 3 mM; 72 h) inhibits cytokine-induced tight junction permeability in Caco-2 cells.Larazotide acetate (12.5 mM; 1 h) inhibits PTG-induced ZO-1 redistribution and actin cytoskeletal rearrangement in IEC6 cells.(In Vivo):Larazotide acetate (250 μg; i.p. twice a week for 7 weeks) inhibits intestinal permeability in gluten-sensitive transgenic mice.

Larazotide acetate(1-100 μM; 5 d) affects Vero cell growth.Larazotide acetate(1-100 μM; 3 d) shows antiviral activity to varicella-zoster virus (VZV) with EC50s of 44.14 and 59.06 μM for strain OKA and 07-1, respectively.Larazotide acetate(1 and 3 mM; 72 h) inhibits cytokine-induced tight junction permeability in Caco-2 cells.Larazotide acetate(12.5 mM; 1 h) inhibits PTG-induced ZO-1 redistribution and actin cytoskeletal rearrangement in IEC6 cells. Cell Cytotoxicity Assay Cell Line:Vero cell line Concentration:1-100 μM Incubation Time:5 days Result:Inhibited Vero cell growth with an CC50 value of 82.5 μM.

Larazotide acetate (250 μg; i.p. twice a week for 7 weeks) inhibits intestinal permeability in gluten-sensitive transgenic mice. Animal Model:HLA-HCD4/DQ8 double transgenic mice Dosage:250 μg Administration:Intraperitoneal injection; 250 μg twice a week for 7 weeks Result:Improved barrier function parameters and reduced macrophage counts in the lamina propria to control levels.

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Cytoskeleton/Cell Adhesion Molecules

Gap Junction Protein

Gap Junction Protein

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881851-50-9

785.89

C34H59N9O12

>98% (HPLC)

H2O:16.67 mg/mL (21.21 mM; Need ultrasonic);DMSO:3.2 mg/mL (4.07 mM; Need ultrasonic and warming)

O=C([C@H](C(C)C)NC([C@H](CC(C)C)NC([C@H](C(C)C)NC(CNC(CN)=O)=O)=O)=O)N[C@@H](CCC(N)=O)C(N1[C@@H](CCC1)C(NCC(O)=O)=O)=O.CC(O)=O

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(-20℃)

With Ice Pack

≥ 2 years